N-Acetyl-DL-Tryptophan (abbreviated as NADLT) is a chemically modified tryptophan derivative that holds a unique position and plays a crucial role in the biomedical field. By introducing an acetyl group (-COCH?) to the nitrogen atom of tryptophan, it achieves a significant enhancement in some of its physical and chemical properties.

N-Acetyl-DL-Tryptophan has a chemical formula of C??H??N?O?, a molecular weight of 246.26, and a CAS number of 87-32-1. It appears as white flaky crystals.

Thanks to the protection of the acetyl group, N-Acetyl-DL-Tryptophan exhibits better stability than tryptophan, particularly in terms of antioxidant capacity. Ordinary tryptophan is prone to structural changes or loss of activity due to oxidation, whereas N-Acetyl-DL-Tryptophan can maintain the stability of its structure and properties under the protection of the acetyl group. This stability gives it distinct advantages in the field of pharmaceutical formulations. Pharmaceutical formulations often encounter various complex environmental factors during storage and use; poor stability may lead to reduced drug efficacy or even the occurrence of adverse reactions. However, the excellent stability of N-Acetyl-DL-Tryptophan provides strong assurance for the quality and effectiveness of pharmaceutical formulations.

Another important advantage of N-Acetyl-DL-Tryptophan is its good solubility—it is more soluble in water than tryptophan. During the preparation of pharmaceutical formulations, good solubility means that it can be more evenly dispersed in solvents and mixed more easily with other ingredients, thereby improving the uniformity and stability of the formulations. This makes it easier to use in formulations; whether it is made into solutions, injections, or other dosage forms, it can better meet the requirements of the formulation process. It is worth noting that N-Acetyl-DL-Tryptophan is an amphoteric compound, with both acidic and basic groups in its molecular structure. This special property allows it to exhibit different charge states depending on the solvent environment. In an acidic environment, its basic groups will combine with hydrogen ions, making the molecule carry a positive charge; in an alkaline environment, its acidic groups will release hydrogen ions, and the molecule will carry a negative charge. This characteristic of changing charge states with the environment further expands its application potential in different fields.

In practical applications, N-Acetyl-DL-Tryptophan demonstrates important value in multiple aspects. Under conditions of oxidative stress and heat stress, it can significantly reduce the degradation of antibodies and maintain their biological activity. The incorporation of N-Acetyl-DL-Tryptophan into some monoclonal antibody pharmaceutical formulations ensures that the antibody drugs maintain better stability in complex environments, thereby extending the drug storage period.

N-Acetyl-DL-Tryptophan is also widely used as a stabilizer in human serum albumin formulations.?Human serum albumin is an important plasma protein and plays an indispensable role in maintaining the normal physiological functions of the human body. During the preparation of human serum albumin formulations, protein aggregation and agglutination are common issues, which can affect the quality and stability of the formulations and may even lead to adverse reactions. N-Acetyl-DL-Tryptophan can prevent protein aggregation and agglutination, thereby improving the stability of the formulations and ensuring the quality and safety of human serum albumin formulations during storage and use.

Furthermore, N-Acetyl-DL-Tryptophan is used in the construction of protein microbubbles.?These protein microbubbles have unique structures and functions; they can effectively protect drug components and prevent them from being rapidly degraded or inactivated in the body. At the same time, protein microbubbles can also improve the delivery efficiency of drug components in the patient's body, enabling drugs to reach the target site more accurately and exert a better therapeutic effect. As a precursor for synthetic peptide drugs and vitamin B1, N-Acetyl-DL-Tryptophan also holds great significance in the field of drug research and development. It provides new ideas and approaches for the development of drugs for the treatment of neurodegenerative diseases (such as Alzheimer's disease).

PanReac AppliChem, a European manufacturer of high-quality biochemical reagents and pharmaceutical excipients, has launched high-quality excipient-grade N-Acetyl-DL-Tryptophan. This product features high purity, low endotoxin levels, and low heavy metal impurities. It complies with the European Pharmacopoeia (Ph. Eur) and British Pharmacopoeia (BP), and has obtained the acceptance number for filing with China's Center for Drug Evaluation (CDE) (F20230000067). It supports global regulatory filings and provides an excellent choice of raw materials and excipients for drug research and commercial production.

Product Information

Product Name	Item No.	Specification
N-Acetyl-DL-Tryptophan (Ph. Eur, BP) low endotoxin, IPEC grade	637763.1210	500g
	637763.0914	5kg
	637763.0416	25kg

PanReac AppliChem?is one of the high-quality producers of biochemical reagents and pharmaceutical raw materials from Europe. With a century-long history, it has obtained multiple ISO quality management system certifications and serves as a key supplier to global life science research institutions, well-known CRO/CDMO enterprises, and large industrial companies in fields such as pharmaceuticals, diagnostics, food, and cosmetics.

As a long-term and fixed supplier to numerous world-renowned culture medium manufacturers and pharmaceutical companies, PanReac AppliChem is among the few global producers capable of providing a wide range of pharmacopoeia-grade and cell culture-grade raw materials. It offers a comprehensive portfolio of chemicals across grades including cell culture grade, pharmacopoeia grade, biochemical grade, and ultra-pure grade. These products cover:

·?Culture medium components: Amino acids, vitamins, antibiotics, salts, buffers, stabilizers, surfactants, etc.

·?Chemicals commonly used in pharmaceutical processes: Tris, guanosine, adenine, sodium caprylate, DMSO (dimethyl sulfoxide), dextran, etc.

XMJ?is the?exclusive distributor?of AppliChem in China, providing customers with comprehensive technical support and after-sales service. If you are interested in the products, please feel free to:

·?Call XMJ’s customer service hotline:?400-050-4006

·?Visit the official website:?www.gp82.cn?for more information.